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Science

Our Approach

Embody's regenerative implants contain fibers of the size and strength resembling healthy adult tissue. Our grafts are designed to promote cellular infiltration and regeneration of host tissue, while providing the required mechanobiological forces to drive recovery and remodeling. These features are unique to our patent-pending medical devices due to our biofabrication technologies, chemistries, and rational biomaterial feedstock selections.

Embody appreciates that there are significant differences across clinical indications and anatomical locations, requiring the device design to fit the clinical need. However, the last two decades of orthopedic surgery have seen the use of cadaveric dermis (harvested skin) in a “one-size-fits-all” approach. This approach has given rise to a large population of unfavorable patient outcomes and shown the need for purpose built products.

A natural polymer and the most abundant protein in the human body, collagen is the fundamental extracellular matrix (ECM) component of tendons, ligaments and connective tissues. Collagen also serves as a biological material that supports the adhesion, orientation, differentiation and proliferation of cells. We recognize that it is imperative to design tissue guiding implants with collagen to promote a vastly superior healing response.

Our Technology

The importance of collagen is well understood within the medical industry, and collagen-based regenerative matrices have been widely used in applications such as drug delivery and wound healing. However, for soft tissue repair, the historical challenge of collagen-based implants has been creating a graft with sufficient biomechanical performance. Embody is leveraging our creative chemistries and improving upon two separate advanced manufacturing platforms, electrospinning and microfluidics, to address these prior limitations.

Microfluidic Biofabrication

Microfluidics is emerging as a material fabrication technique to enable precise chemical reactions and subsequent deposition of small volumes of fluid, analogous to how an ink-jet printer prints words on a page. We pioneered a methodology to precisely control the molecular assembly of collagen into small-micron fibers with unprecedented spatiotemporal fidelity. Precise placement of the fibers during the biofabrication process allows us to move beyond the limits of what was previously possible.

Electrospinning

Electrospinning is a fiber production method which uses electric force to draw charged threads of polymer solutions or polymer melts up to fiber diameters in the order of some hundred nanometers. Electrospinning can be used to form regenerative collagen-based matrices with regular, highly aligned architecture. Our grafts produced using this technique mimic the consistency and microarchitecture of human tendons and ligaments.

The Embody Difference

Robust Cellular Response

Our highly aligned nano-fibers show have shown a massive cellular response for attachment, infiltration, and a rapid developmental response for the production of tendon-like tissue.

Embody Tendon Repair Matrix

Our regenerative matrices, based on proprietary manufacturing technology, mimics native tissue fiber size and alignment. With our products we aim to promote a regenerative response in the patient, accelerating and improving recovery.